Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 2/20 | 0.64 |
| ▸ | SNCA | P37840 | 3/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HTR1D | P28221 | 5/20 | 0.55 |
| ▸ | HTR1B | P28222 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HTR1F | P30939 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL10579379 | 0.80 | KDM4E (0.60) | MPOMAPTHTR1DHTR1BHTR1A | |
| SCHEMBL7141265 | 0.79 | HTR1F (0.76) | SNCAMAPTHTR1DHTR1BHTR1A | |
| SCHEMBL2404396 | 0.79 | MPO (1.00) | MPOHTR1DHTR1BHTR1AKDM4E | |
| SCHEMBL7860320 | 0.78 | HTR1F (0.50) | MPOMAPTHTR1DHTR1BHTR1A | |
| SCHEMBL9256341 | 0.78 | MPO (0.53) | MPOSNCASIRT1MAPTHTR1D | |
| SCHEMBL12352653 | 0.77 | KDM4E (0.70) | MPOMAPTHTR1DHTR1BHTR1A | |
| SCHEMBL7860323 | 0.76 | MMP2 (0.49) | HTR1DHTR1BHTR1AHTR1FMEN1 | |
| SCHEMBL11359819 | 0.76 | HTR1A (0.71) | MPOMAPTHTR1DHTR1BHTR1A | |
| SCHEMBL20182262 | 0.76 | TRPV1 (0.73) | SNCASIRT1MAPTKDM4EMTNR1A | |
| Hydrochloric Acid SCHEMBL8194413 | 0.76 | HTR1F (0.47) | MPOSNCAMAPTHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1083918-A1 | NOVEL THERAPEUTIC AGENTS THAT MODULATE 5-HT RECEPTORS | Advanced Medicine, Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999064044-A1 | NOVEL THERAPEUTIC AGENTS THAT MODULATE 5-HT RECEPTORS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |