Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.49 |
| ▸ | WNT3A | P56704 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7166019 | 0.87 | RAB9A (0.69) | RAB9ANPC1ALDH1A1TDP1MAPT | |
| SCHEMBL9049629 | 0.84 | NPC1 (0.74) | RAB9ANPC1ALDH1A1TDP1MAPT | |
| SCHEMBL715536 | 0.82 | CYP3A4 (0.56) | RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10501527 | 0.81 | ACHE (0.46) | RAB9ANPC1ALDH1A1TDP1MAPT | |
| SCHEMBL9320692 | 0.80 | RAB9A (0.64) | RAB9ANPC1ALDH1A1TDP1MAPT | |
| SCHEMBL11380014 | 0.79 | LMNA (0.50) | RAB9ANPC1ALDH1A1TDP1MAPT | |
| Hydrochloric Acid SCHEMBL11194556 | 0.79 | PPARG (0.46) | RAB9ANPC1ALDH1A1TDP1MAPT | |
| SCHEMBL9137382 | 0.79 | LMNA (0.56) | RAB9ANPC1ALDH1A1TDP1MAPT | |
| SCHEMBL5314324 | 0.78 | ELANE (0.70) | RAB9ANPC1ALDH1A1TDP1MAPT | |
| SCHEMBL27628173 | 0.78 | RAB9A (0.69) | RAB9ANPC1ALDH1A1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316405-B1 | CYCLOSPORIN A, POLYPEPTIDES, COMPONENT OF AMYLOID PLAQUES FOUND IN NEUROLOGICAL DISORDERS SUCH AS ALZHEIMER'S DISEASE, MULTIPLE SCLEROSIS, AND AMYOTROPHIC LATERAL SCLEROSIS. THE CONJUGATES ARE USEFUL IN THE TREATMENT OF NEUROLOGICAL | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2001-11-13 | — | — | US | disclosed |