Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6569729 | 0.84 | GPR52 (0.50) | CYP1A2POLBKDM4EALDH1A1GPR52 | |
| SCHEMBL11516112 | 0.74 | POLB (0.42) | CYP1A2POLBKDM4EALDH1A1NPC1 | |
| SCHEMBL5471638 | 0.74 | ALDH1A1 (0.49) | POLBKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL8091560 | 0.74 | ALDH1A1 (0.46) | CYP1A2POLBKDM4EALDH1A1GPR52 | |
| SCHEMBL5805649 | 0.73 | ALDH1A1 (0.49) | CYP1A2POLBKDM4EALDH1A1NPC1 | |
| SCHEMBL1255865 | 0.71 | LOXL2 (0.43) | CYP1A2KDM4EALDH1A1LOXL2NPC1 | |
| SCHEMBL270347 | 0.70 | — | — | |
| SCHEMBL1383658 | 0.68 | G6PC1 (0.50) | POLBKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL27411167 | 0.68 | LOXL2 (0.54) | CYP1A2ALDH1A1LOXL2GPR52MEN1 | |
| SCHEMBL7471622 | 0.68 | ALDH1A1 (0.46) | CYP1A2KDM4EALDH1A1LOXL2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316496-B1 | FOR THERAPY OF RETROVIRAL INFECTION; PROPHYLAXIS OF REPLICATION OF RETROVIRUS, THERAPY OF AIDS (ACQUIRED IMMUNE DEFICIENCY SYNDROME) | G. D. SEARLE & CO. | 2001-11-13 | — | — | US | disclosed |