Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.45 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6569729 | 0.89 | GPR52 (0.50) | ALDH1A1NPC1RAB9AG6PC1GPR52 | |
| SCHEMBL1383658 | 0.77 | G6PC1 (0.50) | ALDH1A1NPC1RAB9AG6PC1MAPT | |
| SCHEMBL921218 | 0.76 | ALDH1A1 (0.48) | ALDH1A1MAPTPOLBKDM4ELMNA | |
| SCHEMBL499995 | 0.74 | ALDH1A1 (0.50) | ALDH1A1MAPTPOLBKDM4ELMNA | |
| SCHEMBL7870040 | 0.74 | CYP1A2 (0.39) | ALDH1A1NPC1RAB9AG6PC1GPR52 | |
| SCHEMBL11842565 | 0.73 | ALDH1A1 (0.49) | ALDH1A1MAPTPOLBKDM4ELMNA | |
| SCHEMBL3384654 | 0.73 | ALDH1A1 (0.49) | ALDH1A1MAPTPOLBKDM4ELMNA | |
| SCHEMBL4720997 | 0.72 | SIGMAR1 (0.46) | ALDH1A1L3MBTL1HPGDALOX12MAPK1 | |
| SCHEMBL268821 | 0.72 | ALDH1A1 (0.44) | ALDH1A1NPC1RAB9AG6PC1GPR52 | |
| SCHEMBL5471638 | 0.72 | ALDH1A1 (0.49) | ALDH1A1G6PC1MAPTPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037370-A | TREATING ALZHEIMER*S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, PARKINSON*S DISEASE, AND OTHER NERVOUS SYSTEM DISORDERS WITH PEPTIDE DERIVATIVES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-03-14 | — | — | US | disclosed |