Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | DRD4 | P21917 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | ACKR3 | P25106 | 14/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7875925 | 0.86 | DRD2 (0.54) | DRD2DRD4DRD3NPC1ALDH1A1 | |
| SCHEMBL5160839 | 0.81 | DRD2 (0.53) | DRD2DRD4DRD3NPC1RAB9A | |
| SCHEMBL6662366 | 0.77 | NPC1 (0.52) | DRD2DRD4DRD3KDM4ENPC1 | |
| SCHEMBL7158123 | 0.76 | AKT3 (0.52) | DRD2DRD4DRD3NPC1RAB9A | |
| SCHEMBL5160692 | 0.75 | HTR1A (0.59) | RAB9A | |
| SCHEMBL5160955 | 0.75 | HTR1A (0.60) | DRD2DRD4DRD3KDM4ENPC1 | |
| SCHEMBL7877508 | 0.75 | HDAC6 (0.50) | SNCAHDAC1 | |
| SCHEMBL7160985 | 0.74 | ESRRG (0.52) | DRD2DRD4DRD3ACKR3ALDH1A1 | |
| SCHEMBL6660894 | 0.73 | HCN1 (0.53) | DRD2DRD4DRD3KDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL7154175 | 0.73 | ESRRG (0.50) | DRD2DRD4DRD3ACKR3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020183011-A1 | HTR1D INHIBITORS AND USES THEREOF IN THE TREATMENT OF CANCER | INSTITUT CURIE (FR) | 2020-09-17 | — | — | WO | disclosed |
| US-6323229-B1 | COMPOUNDS ARE USEFUL PSYCHOTHERAPEUTICS AND ARE POTENT AGONISTS AND/OR ANTAGONISTS OF THE SEROTONIN 1A (5-HT 1A) AND/OR SEROTONIN 1D (5-HT 1D) FOR TREATMENT OF HYPERTENSION, DEPRESSION, GENERALIZED ANXIETY DISORDER | PFIZER INC | 2001-11-27 | — | — | US | disclosed |
| US-6197773-B1 | HEADACHES; ANTIDEPRESSANTS | PFIZER INC | 2001-03-06 | — | — | US | disclosed |