Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10583975 | 0.80 | MEN1 (0.35) | ALDH1A1LMNASMN1; SMN2KMT2AHTT | |
| SCHEMBL7872104 | 0.73 | CHRNB2 (0.46) | CHRNB2CHRNB4CHRNA3CHRNA4EGFR | |
| SCHEMBL11404152 | 0.67 | EGFR (0.45) | CHRNB2CHRNB4CHRNA3CHRNA4EGFR | |
| SCHEMBL27670390 | 0.67 | RAB9A (0.37) | POLBSMN1; SMN2KMT2ANPC1RAB9A | |
| SCHEMBL1818244 | 0.66 | TSHR (0.43) | CHRNB2CHRNB4CHRNA3CHRNA4EGFR | |
| SCHEMBL7260977 | 0.66 | AKR1C3 (0.37) | POLBLMNA | |
| SCHEMBL10513500 | 0.64 | CPB2 (0.36) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL1139982 | 0.64 | MLYCD (0.54) | CHRNB2CHRNB4CHRNA3CHRNA4POLB | |
| SCHEMBL1239045 | 0.64 | KMT2A (0.51) | EGFRERBB2POLBALDH1A1LMNA | |
| SCHEMBL4425563 | 0.64 | TSHR (0.46) | CHRNB2CHRNB4CHRNA3CHRNA4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323344-B1 | HYDROLYZING 5-BENZOYL-2,3-DIHYDRO-1H-PYRROLIZINE-1-CARBOXAMIDES COMPOUND IN PRESENCE OF STRONG BASE TO FORM KETOROLAC | SYNTEX (U.S.A.) INC. | 2001-11-27 | — | — | US | disclosed |
| US-6197976-B1 | ACYLATION, SALT FORMATION, DEAMINATION | SYNTEX (U.S.A.) LLC | 2001-03-06 | — | — | US | disclosed |