Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.41 |
| ▸ | PTAFR | P25105 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869540 | 0.87 | MEN1 (0.46) | MEN1KMT2AMAPT | |
| SCHEMBL8329396 | 0.78 | MEN1 (0.46) | MEN1KMT2AMAPT | |
| SCHEMBL7776463 | 0.77 | ROCK2 (0.41) | CRBNPTAFRRPS6KA5 | |
| SCHEMBL9384000 | 0.76 | POLB (0.38) | PTAFRMEN1KMT2ARPS6KA5MAPT | |
| SCHEMBL7876035 | 0.76 | ALOX15 (0.48) | MEN1KMT2AHPGD | |
| SCHEMBL7776583 | 0.75 | RPS6KA5 (0.42) | CRBNRPS6KA5CYP2D6S1PR1CYP2C19 | |
| SCHEMBL9559464 | 0.74 | HSD17B10 (0.47) | MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL9727194 | 0.73 | TP53 (0.46) | MEN1KMT2AMAPT | |
| SCHEMBL9726878 | 0.73 | MAPK1 (0.52) | HTTMAPT | |
| SCHEMBL24477016 | 0.72 | RPS6KA5 (0.49) | CRBNRPS6KA5HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6306853-B1 | DICARBOXYLIC ESTER DERIVATIVES OF DIHYDROPYRIDINE COMPOUNDS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-10-23 | — | — | US | disclosed |
| EP-1055672-A1 | 1,4-DIHYDROPYRIDINE DERIVATIVES | Nikken Chemicals Company, Limited (JP) | 2000-11-29 | — | — | EP | disclosed |