Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876539 | 0.81 | SMN1; SMN2 (0.46) | — | |
| SCHEMBL7879161 | 0.79 | GRIK1 (0.43) | ALOX5CYP2D6 | |
| SCHEMBL4290877 | 0.79 | GRIK1 (0.43) | ALOX5CYP2D6 | |
| SCHEMBL7873373 | 0.78 | LTB4R (0.44) | ALOX5CYP2D6TRPA1 | |
| SCHEMBL7953565 | 0.75 | FDFT1 (0.43) | — | |
| SCHEMBL7874826 | 0.74 | CTSB (0.42) | ALOX5CYP2D6 | |
| SCHEMBL7956778 | 0.73 | HTR2A (0.46) | — | |
| SCHEMBL7956781 | 0.73 | HTR2A (0.46) | — | |
| SCHEMBL7593804 | 0.72 | ALOX5 (0.53) | ALOX5CYP2D6 | |
| SCHEMBL5949584 | 0.72 | ALOX5 (0.53) | ALOX5CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |