Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4290877 | 0.83 | GRIK1 (0.43) | MEN1CYP2D6CYP2C9CYP2C19KMT2A | |
| SCHEMBL7879161 | 0.83 | GRIK1 (0.43) | MEN1CYP2D6CYP2C9CYP2C19KMT2A | |
| SCHEMBL7873373 | 0.82 | LTB4R (0.44) | CYP2D6CYP2C9CYP2C19KMT2AALOX5 | |
| SCHEMBL7876532 | 0.81 | LTB4R (0.46) | ALOX5 | |
| SCHEMBL7876539 | 0.80 | SMN1; SMN2 (0.46) | SLC1A3SLC1A2SLC1A1MEN1CYP1A2 | |
| SCHEMBL7879180 | 0.77 | CTSB (0.39) | CTSBSLC1A3SLC1A2SLC1A1MEN1 | |
| SCHEMBL7953565 | 0.77 | FDFT1 (0.43) | MMP9MME | |
| SCHEMBL7874835 | 0.76 | FFAR1 (0.44) | MMP9 | |
| SCHEMBL22087968 | 0.76 | MMP3 (0.46) | MMP3MMP9MMP8L3MBTL1MMP1 | |
| SCHEMBL7873355 | 0.74 | ALOX5 (0.40) | CYP2D6ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |