Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 6/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | BCL9 | O00512 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 2/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28334181 | 0.80 | CA12 (0.39) | ALDH1A1IDO1TDO2 | |
| SCHEMBL14775511 | 0.79 | LMNA (0.36) | NPSR1TSHRMAPT | |
| SCHEMBL7699767 | 0.78 | KDM4E (0.39) | SMN1; SMN2NFE2L2ALDH1A1HPGDIDO1 | |
| SCHEMBL9509766 | 0.76 | TUBB4A (0.43) | SMN1; SMN2RAB9AALDH1A1HPGDTSHR | |
| SCHEMBL9738424 | 0.73 | ACHE (0.43) | SMN1; SMN2ALDH1A1HPGDTSHRKDM4E | |
| SCHEMBL9538022 | 0.72 | MAOB (0.44) | ALDH1A1KDM4EMAPT | |
| SCHEMBL14450971 | 0.71 | KIF11 (0.52) | SMN1; SMN2RAB9ANPSR1NFE2L2ALDH1A1 | |
| SCHEMBL6575991 | 0.68 | MAPK1 (0.48) | SMN1; SMN2RAB9AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL3294513 | 0.67 | AKR1C3 (0.56) | SMN1; SMN2RAB9ANPSR1KIF11AKR1C3 | |
| SCHEMBL1133231 | 0.66 | AR (0.53) | SMN1; SMN2RAB9ANPSR1NFE2L2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0754176-B1 | NOVEL CARBAMATES AND UREAS AS MODIFIERS OF MULTI-DRUG RESISTANCE | VERTEX PHARMA (US) | 2001-12-05 | — | — | EP | claimed |