Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | BMP1 | P13497 | 2/20 | 0.33 |
| ▸ | MMP12 | P39900 | 2/20 | 0.33 |
| ▸ | TLL1 | O43897 | 1/20 | 0.33 |
| ▸ | TLL2 | Q9Y6L7 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874743 | 0.81 | CYP2C19 (0.48) | MMP3MMP9ADAM17TAS1R3TAS1R1 | |
| SCHEMBL7879214 | 0.78 | SLC1A3 (0.49) | BMP1MMP12TLL1TLL2 | |
| SCHEMBL7876984 | 0.76 | SLC1A3 (0.43) | TAS1R3TAS1R1 | |
| SCHEMBL7876948 | 0.76 | SLC1A3 (0.40) | RIPK1BMP1MMP12TLL1TLL2 | |
| SCHEMBL7879220 | 0.75 | KMT2A (0.42) | RIPK1BMP1MMP12TLL1TLL2 | |
| SCHEMBL7876864 | 0.71 | CYP2C19 (0.40) | ADAM17RIPK1BMP1MMP12TLL1 | |
| SCHEMBL7874813 | 0.71 | PPARG (0.44) | MMP9BMP1MMP12TLL1TLL2 | |
| SCHEMBL7876572 | 0.71 | BMP1 (0.34) | MMP3MMP9ADAM17BMP1MMP12 | |
| SCHEMBL7876857 | 0.71 | NR4A2 (0.40) | TAS1R3TAS1R1BMP1MMP12TLL1 | |
| SCHEMBL7384854 | 0.70 | ADAM17 (0.36) | MMP3MMP9ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | claimed |