Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.46 |
| ▸ | HRH1 | P35367 | 3/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700249 | 0.76 | ADRA1A (0.57) | TSHRADRA1AHRH1ADRA1BCYP1A2 | |
| SCHEMBL10482471 | 0.74 | ADRA1A (0.61) | TSHRADRA1AHRH1ADRA1BCYP1A2 | |
| SCHEMBL7894969 | 0.73 | TSHR (0.66) | TSHRADRA1AHRH1ADRA1BCYP1A2 | |
| SCHEMBL10700300 | 0.69 | ADRA1A (0.55) | TSHRADRA1AHRH1ADRA1BCYP1A2 | |
| SCHEMBL10700164 | 0.68 | ADRA1A (0.55) | TSHRADRA1AHRH1ADRA1BCYP1A2 | |
| SCHEMBL10698694 | 0.68 | ADRA1A (0.62) | TSHRADRA1AHRH1ADRA1BSMN1; SMN2 | |
| SCHEMBL9570448 | 0.67 | TSHR (0.62) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1787363 | 0.67 | TSHR (0.61) | TSHRADRA1AHRH1ADRA1BCYP1A2 | |
| SCHEMBL8556390 | 0.67 | ENPP1 (0.65) | TSHRADRA1AHRH1ADRA1BCYP1A2 | |
| SCHEMBL15478270 | 0.66 | TSHR (0.82) | TSHRADRA1AHRH1ADRA1BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180629-B1 | INDUCING OR PROMOTING APOPTOSIS AND FOR ARRESTING UNCONTROLLED NEOPLASTIC CELL PROLIFERATION, INCLUDING PRECANCEROUS AND CANCEROUS LESIONS | CELL PATHWAYS, INC. | 2001-01-30 | — | — | US | disclosed |