Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 10/20 | 0.62 |
| ▸ | HRH1 | P35367 | 10/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 10/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700300 | 0.86 | ADRA1A (0.55) | ADRA1AHRH1ADRA1BHRH3TSHR | |
| SCHEMBL13890824 | 0.80 | HRH1 (0.72) | ADRA1AHRH1ADRA1BHRH3TSHR | |
| SCHEMBL10482471 | 0.79 | ADRA1A (0.61) | ADRA1AHRH1ADRA1BHRH3TSHR | |
| SCHEMBL10700249 | 0.79 | ADRA1A (0.57) | ADRA1AHRH1ADRA1BHRH3TSHR | |
| SCHEMBL10700979 | 0.78 | HRH1 (0.65) | ADRA1AHRH1ADRA1BHRH3KCNH2 | |
| SCHEMBL10700164 | 0.77 | ADRA1A (0.55) | ADRA1AHRH1ADRA1BHRH3TSHR | |
| SCHEMBL7894969 | 0.75 | TSHR (0.66) | ADRA1AHRH1ADRA1BTSHRUSP2 | |
| Bromide SCHEMBL9690249 | 0.74 | RAB9A (0.59) | TSHRLMNASMN1; SMN2 | |
| SCHEMBL16363659 | 0.74 | TSHR (0.64) | ADRA1AHRH1ADRA1BHRH3TSHR | |
| Talastine SCHEMBL30502 | 0.73 | ADRA1A (0.81) | ADRA1AHRH1ADRA1BHRH3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0289881-A2 | 2-Aminoalkyl-4-benzyl-1-(2H)-phthalazinone derivatives | ASTA Medica Aktiengesellschaft (DE) | 1988-11-09 | — | — | EP | disclosed |