Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | SOS1 | Q07889 | 4/20 | 0.42 |
| ▸ | KRAS | P01116 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11201464 | 0.76 | KMT2A (0.54) | PNMTMAPTALDH1A1CES2BACE1 | |
| SCHEMBL4135956 | 0.75 | PNMT (0.65) | PNMTMAPTALDH1A1L3MBTL1CES2 | |
| SCHEMBL11832003 | 0.74 | UGT2B7 (0.49) | MAPTPTGS2LMNA | |
| SCHEMBL1891721 | 0.73 | CYP2C9 (0.36) | MAPK1MEN1KMT2A | |
| SCHEMBL1891723 | 0.73 | CYP2C9 (0.36) | MAPK1MEN1KMT2A | |
| SCHEMBL14288343 | 0.71 | CDK4 (0.41) | NPC1ALDH1A1PTGS2 | |
| SCHEMBL20272 | 0.71 | KDM4E (0.42) | MAPTNPC1DYRK3CCNT1CCNA2 | |
| SCHEMBL4135655 | 0.70 | PNMT (0.59) | PNMTMAPTALDH1A1L3MBTL1CES2 | |
| SCHEMBL28030276 | 0.70 | ADORA1 (0.41) | NPC1ALDH1A1KMT2A | |
| SCHEMBL10889071 | 0.70 | PNMT (0.54) | PNMTMAPTALDH1A1L3MBTL1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800524-B1 | 6-[TRIAZOLYL[ 3-(TRIFLUOROMETHYL)PHENYL]METHYL]-2-QUINOLINONES AND -QUINOLINETHIONES | JANSSEN PHARMACEUTICA NV (BE) | 2001-10-31 | — | — | EP | disclosed |
| US-5922734-A | NOVEL COMPOUNDS FOR TREATING PSORIASIS AND METHODS FOR THEIR SYNTHESIS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1999-07-13 | — | — | US | disclosed |
| EP-0800524-A1 | 6- TRIAZOLYL 3-(TRIFLUOROMETHYL)PHENYL]METHYL]-2-QUINOLINONES AND -QUINOLINETHIONES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996020200-A1 | 6-[TRIAZOLYL[3-(TRIFLUOROMETHYL)PHENYL]METHYL]-2-QUINOLINONES AND -QUINOLINETHIONES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-07-04 | — | — | WO | disclosed |