Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 6/20 | 0.40 |
| ▸ | PPARD | Q03181 | 4/20 | 0.40 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | PRKX | P51817 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78725 | 0.93 | KDM4E (0.34) | PPARAPPARDPPARGKDM4ELMNA | |
| SCHEMBL78706 | 0.88 | PPARA (0.37) | PPARAPPARDPPARGKDM4ELMNA | |
| SCHEMBL78419 | 0.81 | PDK1 (0.32) | PPARGKDM4ELMNAS1PR5S1PR1 | |
| SCHEMBL78854 | 0.80 | PPARG (0.40) | PPARAPPARDPPARGKDM4ELMNA | |
| SCHEMBL91347 | 0.80 | PPARG (0.38) | PPARAPPARDPPARGKDM4ELMNA | |
| SCHEMBL65792 | 0.79 | PPARA (0.39) | PPARAPPARDPPARGKDM4ELMNA | |
| SCHEMBL64456 | 0.79 | PPARG (0.39) | PPARAPPARDPPARGKDM4ELMNA | |
| SCHEMBL78412 | 0.78 | PPARG (0.39) | PPARAPPARDPPARGKDM4ELMNA | |
| SCHEMBL64056 | 0.78 | PPARG (0.38) | PPARAPPARDPPARGKDM4ELMNA | |
| SCHEMBL64057 | 0.77 | PPARG (0.39) | PPARAPPARDPPARGKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |