Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.39 |
| ▸ | PPARA | Q07869 | 3/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64234 | 0.93 | L3MBTL1 (0.36) | L3MBTL1KDM4ELMNALTA4HMAPT | |
| SCHEMBL65686 | 0.86 | PDK1 (0.38) | MAPTPDE4BCHRM2CHRM4CHRM5 | |
| SCHEMBL65232 | 0.80 | TMEM97 (0.37) | PPARGPPARAPDE4BUSP30 | |
| SCHEMBL64056 | 0.80 | PPARG (0.38) | PPARGPPARAPPARDL3MBTL1KDM4E | |
| SCHEMBL78854 | 0.80 | PPARG (0.40) | PPARGPPARAPPARDL3MBTL1KDM4E | |
| SCHEMBL65792 | 0.79 | PPARA (0.39) | PPARGPPARAPPARDL3MBTL1KDM4E | |
| SCHEMBL78858 | 0.77 | PPARA (0.40) | PPARGPPARAPPARDL3MBTL1KDM4E | |
| SCHEMBL78412 | 0.76 | PPARG (0.39) | PPARGPPARAPPARDL3MBTL1KDM4E | |
| SCHEMBL65814 | 0.76 | PPARG (0.39) | PPARGPPARAPPARDL3MBTL1KDM4E | |
| SCHEMBL78866 | 0.76 | PPARG (0.36) | PPARGPPARAPPARDL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |