Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | PRKX | P51817 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78858 | 0.93 | PPARA (0.40) | KDM4ELMNAS1PR5S1PR1PRKX | |
| SCHEMBL78419 | 0.88 | PDK1 (0.32) | KDM4ELMNAS1PR5S1PR1PRKX | |
| SCHEMBL10289283 | 0.83 | KDM4E (0.33) | KDM4ELMNAL3MBTL1ITGB3ITGA2B | |
| SCHEMBL78706 | 0.81 | PPARA (0.37) | KDM4ELMNAS1PR5S1PR1PRKX | |
| SCHEMBL78724 | 0.80 | KDM4E (0.34) | KDM4ELMNAPPARGPPARDPPARA | |
| SCHEMBL10289281 | 0.80 | FABP4 (0.34) | KDM4ELMNAS1PR5S1PR1PRKX | |
| SCHEMBL64196 | 0.79 | GHSR (0.36) | KDM4ELMNAPPARA | |
| SCHEMBL64503 | 0.78 | PPARA (0.33) | KDM4ELMNAPPARGPPARDPPARA | |
| SCHEMBL78781 | 0.78 | KDM4E (0.36) | KDM4ELMNAL3MBTL1LTA4H | |
| SCHEMBL64233 | 0.78 | CHRM5 (0.35) | KDM4ELMNAL3MBTL1LTA4HITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |