Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.33 |
| ▸ | REN | P00797 | 2/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78724 | 0.93 | KDM4E (0.34) | PPARGPPARAPPARDKDM4ELMNA | |
| SCHEMBL65792 | 0.92 | PPARA (0.39) | PPARGPPARAPPARDKDM4ELMNA | |
| SCHEMBL64056 | 0.90 | PPARG (0.38) | PPARGPPARAPPARDKDM4ELMNA | |
| SCHEMBL78866 | 0.89 | PPARG (0.36) | PPARGPPARAPPARDKDM4ELMNA | |
| SCHEMBL64503 | 0.85 | PPARA (0.33) | PPARGPPARAPPARDKDM4ELMNA | |
| SCHEMBL78404 | 0.85 | PDK1 (0.35) | MEN1KMT2A | |
| SCHEMBL64456 | 0.83 | PPARG (0.39) | PPARGPPARAPPARDKDM4ELMNA | |
| SCHEMBL64233 | 0.83 | CHRM5 (0.35) | KDM4ELMNAL3MBTL1ITGB3ITGA2B | |
| SCHEMBL91275 | 0.83 | PPARG (0.38) | PPARGPPARAPPARDKDM4ELMNA | |
| SCHEMBL64604 | 0.82 | REN (0.52) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |