Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 10/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869112 | 0.74 | METAP1 (0.39) | METAP1CCR6 | |
| SCHEMBL13899831 | 0.69 | — | — | |
| SCHEMBL3965498 | 0.68 | METAP1 (0.41) | METAP1CCR6 | |
| SCHEMBL4631245 | 0.66 | HTR6 (0.39) | METAP1CCR6 | |
| SCHEMBL6865770 | 0.66 | HTR6 (0.39) | METAP1CCR6 | |
| SCHEMBL21496658 | 0.66 | NOS3 (0.35) | NOS3NOS1NOS2 | |
| SCHEMBL3146259 | 0.64 | CA1 (0.45) | CCR6 | |
| SCHEMBL6865388 | 0.64 | CA1 (0.45) | CCR6 | |
| SCHEMBL27350089 | 0.64 | CCR6 (0.36) | METAP1CCR6 | |
| SCHEMBL14228794 | 0.63 | KMT2A (0.47) | CCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37355-E1 | 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds as pharmaceutical active ingredients | GRUENENTHAL GMBH (DE) | 2001-09-04 | — | — | US | disclosed |
| EP-0753506-B1 | 6-Dimethylaminomethyl-1-phenyl-cyclo-hexane compounds as pharmaceutical agents | GRUENENTHAL GMBH (DE) | 1999-08-18 | — | — | EP | disclosed |
| US-5733936-A | ANALGESICS | GRUENENTHAL GMBH (DE) | 1998-03-31 | — | — | US | disclosed |
| EP-0753506-A1 | 6-Dimethylaminomethyl-1-phenyl-cyclo-hexane compounds as pharmaceutical agents | Grünenthal GmbH (DE) | 1997-01-15 | — | — | EP | disclosed |