Sugi Predict

Sugi Predict / Compounds / Tetrahydrofuran

Tetrahydrofuran

Tetrahydrofuran

SCHEMBL8519861

C1CCOC1.Cc1cc(C)c(CNc2c(NC(C)(C)C)c(=O)c2=O)c(C)c1

nearest known ligand 0.33

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Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PLK1 P53350 2/20 0.33
▸ MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7894120 0.89 CHEK2 (0.33) PLK1
SCHEMBL7895615 0.80 L3MBTL1 (0.39) MAPT
SCHEMBL7895628 0.78 ROCK2 (0.32) PLK1
SCHEMBL7887027 0.77 PLK1 (0.35) PLK1
SCHEMBL7894010 0.75 HDAC1 (0.38) PLK1
SCHEMBL7886993 0.73 RPS6KB1 (0.39) MAPT
SCHEMBL7599531 0.72 ALDH1A1 (0.44) —
SCHEMBL7895042 0.71 ALDH1A1 (0.42) MAPT
SCHEMBL7894235 0.69 L3MBTL1 (0.36) PLK1MAPT
SCHEMBL7894170 0.69 KDM4C (0.40) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934257-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-08-11 — — EP disclosed
WO-1998002413-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-01-22 — — WO disclosed