Aminodiphenylmethane

Aminodiphenylmethane

SCHEMBL7897875

C=Cc1ccccc1C=C.NC(c1ccccc1)c1ccccc1

nearest known ligand 0.64

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Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.48
DPP4 P27487 2/20 0.44
F2 P00734 1/20 0.44
ADRA2A P08913 1/20 0.40
ADRA2C P18825 1/20 0.40
LMNA P02545 1/20 0.40
HIF1A Q16665 1/20 0.40
KDM4E B2RXH2 1/20 0.40
TSHR P16473 1/20 0.39
SLC6A2 P23975 1/20 0.36
SLC6A4 P31645 1/20 0.36
SLC6A3 Q01959 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8387067 0.89 LMNA (0.40) ALDH1A1DPP4F2ADRA2AADRA2C
Hydrochloric Acid SCHEMBL5493379 0.87 LMNA (0.39) ALDH1A1DPP4F2ADRA2AADRA2C
SCHEMBL7460522 0.85 DPP4 (0.39) ALDH1A1DPP4F2ADRA2AADRA2C
Aminodiphenylmethane SCHEMBL9499747 0.82 ALDH1A1 (0.56) ALDH1A1DPP4F2ADRA2AADRA2C
Aminodiphenylmethane SCHEMBL4340486 0.82 ALDH1A1 (0.64) ALDH1A1DPP4F2ADRA2AADRA2C
Aminodiphenylmethane SCHEMBL11059631 0.81 DPP4 (0.48) ALDH1A1DPP4F2ADRA2AADRA2C
Benzene SCHEMBL438681 0.80 ALDH1A1 (0.60) ALDH1A1LMNATSHR
Aminodiphenylmethane SCHEMBL7841 0.80 DPP4 (0.65) DPP4F2ADRA2AADRA2CLMNA
SCHEMBL8773900 0.77 ALDH1A1 (0.43) ALDH1A1DPP4F2LMNAKDM4E
Aminodiphenylmethane SCHEMBL8686295 0.77 DPP4 (0.61) DPP4F2ADRA2AADRA2CLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6194544-B1 COMBINATORIAL LIBRARY OF SETS OF CYCLIC PENTAPEPTIDES OR HEXAPEPTIDES HAVING CONFORMATIONALLY CONTSTRAINING ELEMENTS; SCREENING FOR NEW BIOACTIVE PEPTIDES; DETERMINING STRUCTURAL INFORMATION IMPORTANT IN DRUG DESIGN SMITHKLINE BEECHAM CORPORATION 2001-02-27 US disclosed
EP-0788370-A4 CYCLIC SEMI-RANDOM PEPTIDE LIBRARIES SMITHKLINE BEECHAM CORP (US) 1998-07-08 EP disclosed
EP-0788370-A1 CYCLIC SEMI-RANDOM PEPTIDE LIBRARIES SMITHKLINE BEECHAM CORPORATION (US) 1997-08-13 EP disclosed
WO-1995001800-A1 CYCLIC SEMI-RANDOM PEPTIDE LIBRARIES SMITHKLINE BEECHAM CORPORATION (US) 1995-01-19 WO disclosed
EP-0138416-B1 GROWTH HORMONE RELEASE FACTOR ANALOGS ELI LILLY AND COMPANY (US) 1993-04-28 EP disclosed
US-4617149-A ANIMAL GROWTH REGULATORS ELI LILLY AND COMPANY (US) 1986-10-14 US disclosed
EP-0138416-A2 Growth hormone release factor analogs ELI LILLY AND COMPANY (US) 1985-04-24 EP disclosed