Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26725468 | 0.80 | MBTD1 (0.42) | MBTD1L3MBTL3 | |
| SCHEMBL20833280 | 0.80 | MBTD1 (0.42) | MBTD1L3MBTL3 | |
| SCHEMBL7900993 | 0.75 | MBTD1 (0.35) | CHRNB2CHRNA4MBTD1L3MBTL3CHRNA3 | |
| SCHEMBL24399967 | 0.75 | DRD2 (0.41) | CYP2D6DRD2DRD3 | |
| SCHEMBL7899298 | 0.74 | MBTD1 (0.34) | MBTD1L3MBTL3CHRNA3 | |
| SCHEMBL7899195 | 0.72 | DPP4 (0.43) | — | |
| SCHEMBL7899197 | 0.72 | DPP4 (0.43) | — | |
| SCHEMBL7899159 | 0.71 | DRD2 (0.41) | CYP2D6DRD2DRD3MBTD1L3MBTL3 | |
| SCHEMBL8186354 | 0.71 | CHRNB2 (0.38) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL8186570 | 0.70 | CHRNB2 (0.37) | CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184229-B1 | 6-pyrrolidin-2-ylpyrindine derivatives, their preparation and application in therapy | SANOFI-SYNTHELABO (FR) | 2001-02-06 | — | — | US | disclosed |
| EP-1000056-A1 | 6-PYRROLIDIN-2-YLPYRINDINE DERIVATIVES, THEIR PREPARATION AND APPLICATION IN THERAPY | SANOFI-SYNTHELABO (FR) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999002517-A1 | 6-PYRROLIDIN-2-YLPYRINDINE DERIVATIVES, THEIR PREPARATION AND APPLICATION IN THERAPY | SANOFI-SYNTHELABO (FR) | 1999-01-21 | — | — | WO | disclosed |