Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7899159 | 0.79 | DRD2 (0.41) | MBTD1L3MBTL3HTR2AHTR2CHTR2B | |
| SCHEMBL7898064 | 0.75 | CHRNB2 (0.37) | MBTD1L3MBTL3CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL20833280 | 0.72 | MBTD1 (0.42) | MBTD1L3MBTL3OPRM1OPRL1 | |
| SCHEMBL26725468 | 0.72 | MBTD1 (0.42) | MBTD1L3MBTL3OPRM1OPRL1 | |
| SCHEMBL7899298 | 0.70 | MBTD1 (0.34) | MBTD1L3MBTL3CHRNA3HTR2AHTR2C | |
| SCHEMBL13998647 | 0.65 | HTR2A (0.40) | HTR2AHTR2CHTR2BCHRNB2CHRNA4 | |
| SCHEMBL12669982 | 0.65 | CHRNB2 (0.36) | HTR2AHTR2CHTR2BCHRNB2CHRNA4 | |
| SCHEMBL27981835 | 0.63 | PNMT (0.51) | — | |
| SCHEMBL31621633 | 0.62 | P2RX7 (0.36) | CHRNB2CHRNA4 | |
| SCHEMBL12891917 | 0.62 | DRD2 (0.39) | HTR2AHTR2CHTR2BCHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184229-B1 | 6-pyrrolidin-2-ylpyrindine derivatives, their preparation and application in therapy | SANOFI-SYNTHELABO (FR) | 2001-02-06 | — | — | US | disclosed |