Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900993 | 0.79 | MBTD1 (0.35) | HTR2AHTR2CHTR2BMBTD1L3MBTL3 | |
| SCHEMBL7898064 | 0.71 | CHRNB2 (0.37) | DRD2DRD3CYP2D6MBTD1L3MBTL3 | |
| SCHEMBL26725468 | 0.69 | MBTD1 (0.42) | GRIN1GRIN2AHTR1AMBTD1L3MBTL3 | |
| SCHEMBL20833280 | 0.69 | MBTD1 (0.42) | GRIN1GRIN2AHTR1AMBTD1L3MBTL3 | |
| SCHEMBL12891741 | 0.66 | DRD2 (0.58) | DRD2DRD3DRD1HTR2AHTR2C | |
| SCHEMBL12891740 | 0.66 | DRD2 (0.58) | DRD2DRD3DRD1HTR2AHTR2C | |
| SCHEMBL28871332 | 0.66 | DRD2 (0.51) | DRD2DRD3DRD1HTR2AHTR2C | |
| SCHEMBL31621592 | 0.65 | DRD2 (0.39) | DRD2DRD3DRD1HTR2AHTR2C | |
| SCHEMBL12993416 | 0.65 | DRD2 (0.57) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL7362916 | 0.64 | SLC22A1 (0.52) | DRD2DRD3SLC22A1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184229-B1 | 6-pyrrolidin-2-ylpyrindine derivatives, their preparation and application in therapy | SANOFI-SYNTHELABO (FR) | 2001-02-06 | — | — | US | disclosed |