Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14648365 | 0.85 | GPR55 (0.50) | MAPTGPR55P2RX7MEN1KMT2A | |
| SCHEMBL28093665 | 0.84 | P2RX7 (0.61) | CNR2MAPTP2RX7MEN1KMT2A | |
| SCHEMBL7900604 | 0.81 | CNR2 (0.57) | CNR2P2RX7MEN1KMT2AALDH1A1 | |
| SCHEMBL29171626 | 0.78 | PTPN1 (0.53) | GPR55P2RX7MEN1KMT2APTPN1 | |
| SCHEMBL1397704 | 0.77 | P2RX7 (0.53) | CNR2MAPTP2RX7MEN1KMT2A | |
| SCHEMBL12932448 | 0.77 | P2RX7 (0.75) | GPR55P2RX7MEN1KMT2APOLB | |
| SCHEMBL7206350 | 0.69 | SMN1; SMN2 (0.41) | GPR55P2RX7KMT2AALDH1A1EPHX2 | |
| SCHEMBL2917775 | 0.69 | CNR2 (1.00) | CNR2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL16451620 | 0.69 | ALDH1A1 (0.55) | P2RX7KMT2AALDH1A1EPHX2 | |
| SCHEMBL3021927 | 0.68 | ALDH1A1 (0.59) | P2RX7KMT2AALDH1A1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194450-B1 | KERATINIZATION DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-02-27 | — | — | US | disclosed |
| US-5849798-A | Polyaromatic heterocyclic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-12-15 | — | — | US | disclosed |
| EP-0732328-B1 | Aromatic heterocyclic compounds, pharmaceutical and cosmetic compositions containing them and their uses | CIRD GALDERMA (FR) | 1998-09-09 | — | — | EP | disclosed |
| EP-0732328-A1 | Aromatic heterocyclic compounds, pharmaceutical and cosmetic compositions containing them and their uses | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1996-09-18 | — | — | EP | disclosed |
| US-RE32581-E | Certain substituted phenyl esters of nicotinic acid, compositions and methods of using same for treatment of hyperlipidemia | MERZ + CO. GMBH & CO. (DE) | 1988-01-19 | — | — | US | disclosed |
| US-4412998-A | ANTILIPEMIC | MERZ & COMPANY (DE) | 1983-11-01 | — | — | US | disclosed |
| US-4321268-A | Certain substituted phenyl esters of nicotinic acid, compositions and methods of using same | MERZ & CO. (DE) | 1982-03-23 | — | — | US | disclosed |