Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28093665 | 0.92 | P2RX7 (0.61) | P2RX7MEN1KMT2AFAAHLMNA | |
| SCHEMBL7900490 | 0.77 | CNR2 (0.53) | P2RX7MEN1KMT2AEPHX2MAPT | |
| SCHEMBL14648365 | 0.75 | GPR55 (0.50) | P2RX7MEN1KMT2ALMNAMAPT | |
| SCHEMBL29171626 | 0.75 | PTPN1 (0.53) | P2RX7MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL19524540 | 0.73 | P2RX7 (0.54) | P2RX7MEN1KMT2AFAAHLMNA | |
| SCHEMBL28094069 | 0.73 | P2RX7 (0.38) | P2RX7MEN1KMT2AFAAHLMNA | |
| SCHEMBL7900604 | 0.72 | CNR2 (0.57) | P2RX7MEN1KMT2AEPHX2ALDH1A1 | |
| SCHEMBL4556735 | 0.71 | P2RX7 (0.55) | P2RX7KMT2AFAAHEPHX2 | |
| SCHEMBL19174061 | 0.70 | ALDH1A1 (0.50) | P2RX7KMT2AEPHX2ALDH1A1NPSR1 | |
| SCHEMBL3711556 | 0.69 | KMT2A (0.61) | P2RX7MEN1KMT2ALMNAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7985759-B2 | Dipeptidyl peptidase IV inhibitors and processes for their preparation and pharmaceutical compositions containing them | MATRIX LABORATORIES LTD. (IN) | 2011-07-26 | — | — | US | disclosed |
| EP-2004601-B1 | NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS AND PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MATRIX LAB LTD (IN) | 2011-03-02 | — | — | EP | disclosed |
| US-20100160302-A1 | NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS AND PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MYLAN LABORATORIES LIMITED (IN) | 2010-06-24 | — | — | US | disclosed |
| EP-2004601-A1 | NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS AND PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Matrix Laboratories Limited (IN) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007113634-A1 | NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS AND PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MATRIX LABORATORIES LTD. (DE) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160302-A1 | NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS AND PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DPP4, DPP3, DPP7 | P2RX7 1913/4885MEN1 2315/4885KMT2A 3703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.