Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.57 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14648365 | 0.83 | GPR55 (0.50) | P2RX7MEN1KMT2AALDH1A1MMP2 | |
| SCHEMBL7900490 | 0.81 | CNR2 (0.53) | CNR2P2RX7MEN1KMT2AALDH1A1 | |
| SCHEMBL28093665 | 0.79 | P2RX7 (0.61) | CNR2P2RX7MEN1KMT2AALDH1A1 | |
| SCHEMBL8581921 | 0.78 | CNR2 (0.63) | CNR2P2RX7MEN1KMT2AALDH1A1 | |
| SCHEMBL14086740 | 0.76 | ALDH1A1 (0.62) | CNR2P2RX7MEN1KMT2AALDH1A1 | |
| SCHEMBL29171626 | 0.76 | PTPN1 (0.53) | P2RX7MEN1KMT2AALDH1A1 | |
| SCHEMBL10631943 | 0.75 | HSD11B1 (0.54) | P2RX7MEN1KMT2AHSD11B1 | |
| SCHEMBL4598647 | 0.74 | CNR2 (0.58) | CNR2P2RX7MEN1KMT2AALDH1A1 | |
| SCHEMBL10914317 | 0.72 | MMP2 (0.48) | MEN1KMT2AALDH1A1MMP2MMP9 | |
| SCHEMBL1397704 | 0.72 | P2RX7 (0.53) | CNR2P2RX7MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194450-B1 | KERATINIZATION DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-02-27 | — | — | US | disclosed |
| US-5849798-A | Polyaromatic heterocyclic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-12-15 | — | — | US | disclosed |
| EP-0732328-B1 | Aromatic heterocyclic compounds, pharmaceutical and cosmetic compositions containing them and their uses | CIRD GALDERMA (FR) | 1998-09-09 | — | — | EP | disclosed |
| EP-0732328-A1 | Aromatic heterocyclic compounds, pharmaceutical and cosmetic compositions containing them and their uses | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1996-09-18 | — | — | EP | disclosed |