Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.46 |
| ▸ | THRA | P10827 | 3/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CETP | P11597 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7907310 | 0.96 | THRB (0.46) | THRBTHRAEPHX1EPHX2LMNA | |
| SCHEMBL7900571 | 0.94 | KMT2A (0.42) | THRBTHRAEPHX1EPHX2LMNA | |
| SCHEMBL7900560 | 0.87 | KMT2A (0.44) | THRBTHRAEPHX2LMNAMAPT | |
| SCHEMBL23496620 | 0.87 | THRB (0.52) | THRBTHRAEPHX1EPHX2LMNA | |
| SCHEMBL7910515 | 0.85 | FAAH (0.39) | EPHX2LMNAMAPTCETPMEN1 | |
| SCHEMBL8410990 | 0.83 | THRB (0.44) | THRBTHRAEPHX1EPHX2HRH3 | |
| SCHEMBL8413623 | 0.81 | THRB (0.44) | THRBTHRAEPHX1EPHX2HRH3 | |
| SCHEMBL7907462 | 0.79 | HTR2A (0.38) | EPHX2LMNAHPGDMEN1KMT2A | |
| SCHEMBL8413150 | 0.77 | KMT2A (0.41) | THRBTHRAEPHX1EPHX2MAPT | |
| SCHEMBL9758278 | 0.75 | SPHK1 (0.48) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6210760-B1 | SHORT SWITCHING TIMES AND GRADIENTS AND ANGULAR DEPENDENCIES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2001-04-03 | — | — | US | disclosed |
| US-5876626-A | HIGH SPEED SWITCHING | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-03-02 | — | — | US | disclosed |
| US-5387369-A | With specified mixture of components; short switching times | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |