Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.71 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.57 |
| ▸ | MAOA | P21397 | 2/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | MPO | P05164 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | QPCT | Q16769 | 1/20 | 0.57 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18397817 | 0.86 | ALOX15 (0.64) | LOXL2ALDH1A1MAOAMAOBCYP3A4 | |
| SCHEMBL12325487 | 0.85 | LOXL2 (0.69) | LOXL2AKR1B1ALDH1A1CYP19A1MAOA | |
| SCHEMBL18397814 | 0.85 | LOXL2 (0.97) | LOXL2AKR1B1ALDH1A1CYP19A1MAOA | |
| SCHEMBL9363716 | 0.85 | LOXL2 (0.69) | LOXL2AKR1B1ALDH1A1CYP19A1MAOA | |
| SCHEMBL20873666 | 0.85 | LOXL2 (0.69) | LOXL2AKR1B1ALDH1A1CYP19A1MAOA | |
| SCHEMBL27541788 | 0.85 | LOXL2 (0.69) | LOXL2AKR1B1ALDH1A1CYP19A1MAOA | |
| Hydrochloric Acid SCHEMBL18397740 | 0.83 | LOXL2 (1.00) | LOXL2AKR1B1ALDH1A1CYP19A1MAOA | |
| SCHEMBL10651425 | 0.81 | LOXL2 (0.49) | LOXL2AKR1B1 | |
| SCHEMBL18397741 | 0.81 | LOXL2 (0.49) | LOXL2TNKS | |
| SCHEMBL16972770 | 0.81 | LOXL2 (0.64) | LOXL2AKR1B1ALDH1A1CYP19A1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180215727-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. | 2018-08-02 | — | — | US | disclosed |
| US-20180215727-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. | 2018-08-02 | — | — | US | disclosed |
| US-20180215727-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. | 2018-08-02 | — | — | US | disclosed |
| EP-3325462-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | Pharmakea, Inc. (US) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017015221-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2017-01-26 | — | — | WO | disclosed |
| US-9044409-B2 | Use of chromen-4-one derivatives | MERCK PATENT GMBH (DE) | 2015-06-02 | — | — | US | disclosed |
| US-9044409-B2 | Use of chromen-4-one derivatives | MERCK PATENT GMBH (DE) | 2015-06-02 | — | — | US | disclosed |
| US-20080027133-A1 | USE OF CHROMEN-4-ONE DERIVATIVES | CAROLA CHRISTOPHE | 2008-01-31 | — | — | US | disclosed |
| US-20080027133-A1 | USE OF CHROMEN-4-ONE DERIVATIVES | CAROLA CHRISTOPHE | 2008-01-31 | — | — | US | disclosed |
| US-20070191305-A1 | Chromone complexes | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2007-08-16 | — | — | US | disclosed |
| US-20070191305-A1 | Chromone complexes | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2007-08-16 | — | — | US | disclosed |
| US-6187793-B1 | PSYCHOSIS, SCHIZOPHRENIA; ANTIALLERGENS | FERRER INTERNACIONAL, S.A. (ES) | 2001-02-13 | — | — | US | disclosed |
| EP-0970076-A1 | 7-[(PIPERIDIN-1-YL)- PROPOXY]-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | FERRER INTERNACIONAL, S.A. (ES) | 2000-01-12 | — | — | EP | disclosed |
| WO-1999035144-A1 | 7-[(PIPERIDIN-1-YL)-PROPOXY]-CHROMEN-4-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | FERRER INTERNACIONAL, S.A. (ES) | 1999-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191305-A1 | Chromone complexes | SCO2, CDYL, CYCS | LOXL2 4134/4885AKR1B1 1860/4885ALDH1A1 2949/4885 |
| US-20180215727-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | LOXL2, LOXL1, LOX | LOXL2 1/4885AKR1B1 1053/4885ALDH1A1 982/4885 |
| US-20080027133-A1 | USE OF CHROMEN-4-ONE DERIVATIVES | CYP8B1, CYP7B1, CYP2R1 | LOXL2 1487/4885AKR1B1 59/4885ALDH1A1 212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.