SCHEMBL7901378

SCHEMBL7901378

CCOC(=O)CNc1cc(-n2c(=O)cc(C(F)(F)F)n3ccnc23)c(F)cc1Cl

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.41
PPOX P50336 1/20 0.34
KDM4E B2RXH2 3/20 0.33
ALDH1A1 P00352 2/20 0.33
GAA P10253 2/20 0.33
HPGD P15428 2/20 0.33
CASP1 P29466 2/20 0.33
CASP7 P55210 2/20 0.33
HSD17B10 Q99714 2/20 0.33
ALOX15 P16050 1/20 0.33
POLB P06746 1/20 0.31
SYK P43405 1/20 0.31
CCKAR P32238 1/20 0.30
CCKBR P32239 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7903043 0.92 GAA (0.32) L3MBTL1GAA
SCHEMBL7901544 0.86 PPOX (0.33) PPOX
SCHEMBL7901494 0.84 PPOX (0.50) L3MBTL1PPOXKDM4EALDH1A1GAA
SCHEMBL7901344 0.83 BAZ2B (0.39) PPOXKDM4EALDH1A1GAAHPGD
SCHEMBL7905653 0.83 ALDH1A1 (0.36) L3MBTL1PPOXKDM4EALDH1A1HPGD
SCHEMBL7894127 0.81 MAPK1 (0.31)
SCHEMBL8122021 0.81 MCL1 (0.34)
SCHEMBL7901376 0.80 PPOX (0.50) PPOX
SCHEMBL7894182 0.79 LMNA (0.41) L3MBTL1PPOXKDM4EALDH1A1GAA
SCHEMBL7894121 0.79 PPOX (0.35) PPOXKDM4EALDH1A1HPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6191070-B1 Pyrimidinone derivatives and herbicides containing them SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-02-20 US claimed
US-6191070-B1 Pyrimidinone derivatives and herbicides containing them SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-02-20 US disclosed
EP-0902029-A1 Pyrimidinone derivatives and herbicides containing them SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-03-17 EP disclosed