Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9388439 | 0.79 | ACHE (0.36) | HTR1ADRD2 | |
| SCHEMBL7902262 | 0.70 | HTR1A (0.39) | HTR1ADRD2 | |
| SCHEMBL7904422 | 0.65 | PRCP (0.36) | — | |
| SCHEMBL7904363 | 0.65 | HTR1A (0.42) | HTR1ADRD2 | |
| SCHEMBL9310021 | 0.65 | ADRB2 (0.46) | HTR1ADRD2 | |
| SCHEMBL7902288 | 0.65 | PRCP (0.36) | — | |
| SCHEMBL7904416 | 0.65 | PRCP (0.36) | — | |
| SCHEMBL7904425 | 0.65 | PRCP (0.36) | — | |
| SCHEMBL7903491 | 0.64 | SIGMAR1 (0.32) | — | |
| SCHEMBL7342859 | 0.62 | DRD2 (0.47) | HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6201119-B1 | 2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-9-AMINE COMPOUNDS USEFUL AS INTERMEDIATES TO ANTIVIRALS | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-03-13 | — | — | US | disclosed |
| EP-0417840-B1 | Antiviral tetrahydroimidazo [1,4]-benzodiazepines | JANSSEN PHARMACEUTICA NV (BE) | 1994-12-07 | — | — | EP | disclosed |
| US-5371079-A | Administering to inhibit replication of HIV-1 in human cells | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-12-06 | — | — | US | disclosed |
| US-5270464-A | Anti-HIV-1 tetrahydroimidazo[1,4]benzodiazepin-2-(thi) ones | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-12-14 | — | — | US | disclosed |
| EP-0491751-A1 | ANTIVIRAL TETRAHYDROIMIDAZO 1,4]BENZODIAZEPINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-07-01 | — | — | EP | disclosed |
| WO-1991004255-A1 | ANTIVIRAL TETRAHYDROIMIDAZO[1,4]BENZODIAZEPINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-04-04 | — | — | WO | disclosed |
| EP-0417840-A1 | Antiviral tetrahydroimidazo [1,4]-benzodiazepines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-03-20 | — | — | EP | disclosed |