Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 5/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7903496 | 0.80 | SIGMAR1 (0.32) | OPRD1OPRK1OPRM1 | |
| SCHEMBL7903478 | 0.67 | PNMT (0.31) | — | |
| SCHEMBL24469666 | 0.62 | PARP1 (0.41) | — | |
| SCHEMBL16268940 | 0.61 | HTR1A (0.40) | OPRD1OPRK1OPRM1 | |
| SCHEMBL7904443 | 0.61 | — | — | |
| SCHEMBL14582419 | 0.61 | BRD4 (0.32) | — | |
| SCHEMBL7038907 | 0.60 | KMT2A (0.41) | — | |
| SCHEMBL7896192 | 0.60 | ALOX5 (0.30) | — | |
| SCHEMBL4941638 | 0.58 | MEN1 (0.39) | — | |
| SCHEMBL7902351 | 0.57 | OPRM1 (0.34) | OPRD1OPRK1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6201119-B1 | 2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-9-AMINE COMPOUNDS USEFUL AS INTERMEDIATES TO ANTIVIRALS | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-03-13 | — | — | US | disclosed |
| US-5371079-A | Administering to inhibit replication of HIV-1 in human cells | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-12-06 | — | — | US | disclosed |
| US-5270464-A | Anti-HIV-1 tetrahydroimidazo[1,4]benzodiazepin-2-(thi) ones | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-12-14 | — | — | US | disclosed |