Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.56 |
| ▸ | PDE4A | P27815 | 4/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD1 | P21728 | 2/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7919811 | 0.91 | NFKB1 (0.55) | NFKB1BLMPMP22SIGMAR1 | |
| SCHEMBL7916416 | 0.84 | NFKB1 (0.57) | PDE4BPDE4APDE4CPDE4DNFKB1 | |
| SCHEMBL30352666 | 0.84 | NFKB1 (0.57) | PDE4BPDE4APDE4CPDE4DNFKB1 | |
| SCHEMBL7919807 | 0.83 | NFKB1 (0.51) | PDE4BPDE4APDE4CPDE4DNFKB1 | |
| SCHEMBL7914446 | 0.81 | NFKB1 (0.60) | PDE4BPDE4APDE4CPDE4DNFKB1 | |
| SCHEMBL7906172 | 0.81 | NFKB1 (0.53) | NFKB1BLMPMP22SIGMAR1 | |
| SCHEMBL7906190 | 0.79 | ADRA2A (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7675692 | 0.77 | PDE4A (0.60) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7925777 | 0.77 | PDE4A (0.60) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL29633151 | 0.77 | NFKB1 (0.75) | NFKB1BLMPMP22ADRB2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265402-B1 | ANTIINFLAMMATORY AGENTS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-07-24 | — | — | US | disclosed |
| EP-0924204-A1 | 2-PHENYLMORPHOLIN-5-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-06-23 | — | — | EP | disclosed |