Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.43 |
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
| ▸ | DRD3 | P35462 | 5/20 | 0.43 |
| ▸ | DRD1 | P21728 | 4/20 | 0.43 |
| ▸ | DRD4 | P21917 | 4/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | F7 | P08709 | 2/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7916416 | 0.89 | NFKB1 (0.57) | NFKB1BLMPMP22KMT2ASMPD1 | |
| SCHEMBL30352666 | 0.89 | NFKB1 (0.57) | NFKB1BLMPMP22KMT2ASMPD1 | |
| SCHEMBL7919811 | 0.86 | NFKB1 (0.55) | NFKB1BLMPMP22SIGMAR1 | |
| SCHEMBL6584079 | 0.85 | PDE4B (0.43) | KMT2AADRB2DRD2DRD3DRD1 | |
| SCHEMBL7906188 | 0.83 | PDE4B (0.56) | NFKB1BLMPMP22ADRB2DRD2 | |
| SCHEMBL7148513 | 0.81 | NFKB1 (0.48) | NFKB1BLMPMP22KMT2AADRB2 | |
| SCHEMBL9070525 | 0.81 | NFKB1 (0.48) | NFKB1BLMPMP22KMT2AADRB2 | |
| SCHEMBL13778650 | 0.79 | FDPS (0.45) | KMT2AADRB2DRD2DRD3DRD1 | |
| SCHEMBL7914446 | 0.78 | NFKB1 (0.60) | NFKB1BLMPMP22SMPD1FDPS | |
| SCHEMBL7007168 | 0.78 | HTR1A (0.47) | SMPD1HDAC1HDAC8HDAC6SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265402-B1 | ANTIINFLAMMATORY AGENTS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-07-24 | — | — | US | disclosed |
| EP-0924204-A1 | 2-PHENYLMORPHOLIN-5-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-06-23 | — | — | EP | disclosed |