Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 3/20 | 0.37 |
| ▸ | TPH1 | P17752 | 7/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.34 |
| ▸ | PTGIR | P43119 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylalanine SCHEMBL7906184 | 0.81 | SLC7A5 (0.52) | TPH1ALPIPKMPTGS1XIAP | |
| SCHEMBL7904116 | 0.79 | SLC7A5 (0.45) | TPH1OPRD1ALPIPKMPTGS1 | |
| SCHEMBL7904114 | 0.79 | CYP3A4 (0.37) | TPH1OPRD1ALPIPKMPTGS1 | |
| SCHEMBL7908862 | 0.79 | ALDH1A1 (0.46) | AGTR2TPH1 | |
| SCHEMBL8200203 | 0.79 | TPH1 (0.38) | TPH1OPRD1SLC7A5OPRM1OPRK1 | |
| SCHEMBL7904119 | 0.79 | CYP3A4 (0.38) | TPH1OPRD1ALPIPKMPTGS1 | |
| SCHEMBL7906150 | 0.78 | SLC7A5 (0.43) | TPH1ALPIPKMPTGS1XIAP | |
| SCHEMBL6935180 | 0.76 | DPP4 (0.47) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL6931447 | 0.76 | CTSL (0.40) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL6931449 | 0.75 | ALDH1A1 (0.39) | TPH1ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197794-B1 | ANTIINFLAMAMTORY AGENTS; IMMUNOLOGY DISEASES | CELLTECH THERAPEUTICS LIMITED (GB) | 2001-03-06 | — | — | US | disclosed |