Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19624259 | 0.81 | NFKB1 (0.51) | MAPTNPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL375687 | 0.81 | PDE4B (0.44) | KMT2AMAPTRAB9ASMN1; SMN2PDE4B | |
| SCHEMBL31572377 | 0.79 | PDE4B (0.44) | MEN1KMT2AMAPTPDE4BPDE4D | |
| SCHEMBL31469077 | 0.76 | SYK (0.41) | MEN1KMT2AMAPTTP53RAB9A | |
| SCHEMBL31491328 | 0.75 | KIF11 (0.41) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL30542633 | 0.74 | PDE4B (0.50) | PDE4BPDE4DDHODH | |
| SCHEMBL29056205 | 0.74 | PDE4B (0.50) | PDE4BPDE4DDHODH | |
| SCHEMBL31469083 | 0.74 | PDE4B (0.47) | PDE4BPDE4D | |
| SCHEMBL31572403 | 0.74 | PDE4B (0.43) | PDE4BPDE4DDHODH | |
| SCHEMBL13211477 | 0.74 | HPGD (0.46) | MEN1KMT2AMAPTTP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097334-A1 | DRUG COMBINATIONS CONTAINING PDE4 INHIBITORS AND NSAIDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |