Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7905773 | 0.94 | BACE1 (0.39) | PRKDCFLT3BACE1AXLUSP2 | |
| SCHEMBL7904730 | 0.88 | FLT3 (0.40) | PRKDCFLT3BACE1AXLUSP2 | |
| SCHEMBL7904007 | 0.87 | USP2 (0.40) | FLT3BACE1AXLUSP2KDM4E | |
| SCHEMBL7896551 | 0.86 | CNR2 (0.36) | FLT3BACE1AXLUSP2KDM4E | |
| SCHEMBL7908577 | 0.85 | FLT3 (0.39) | PRKDCFLT3BACE1AXLUSP2 | |
| SCHEMBL7905726 | 0.84 | FLT3 (0.40) | FLT3USP2KDM4EKDM1AABL1 | |
| SCHEMBL7904450 | 0.84 | FLT3 (0.40) | PRKDCFLT3USP2KDM4EKDM1A | |
| SCHEMBL7908481 | 0.84 | PIK3CB (0.44) | PRKDCBACE1AXLKDM4EPIK3CA | |
| SCHEMBL7896411 | 0.79 | USP2 (0.43) | FLT3USP2KDM4ECYP2D6POLB | |
| SCHEMBL7905966 | 0.78 | CYP2D6 (0.49) | FLT3BACE1AXLKDM4EPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191152-B1 | CARDIOVASCULAR DISORDERS, NERVOUS SYSTEM DISORDERS | EGIS GYÓGYSZERGYAR RT. (HU) | 2001-02-20 | — | — | US | disclosed |