SCHEMBL7915330

SCHEMBL7915330

CCNC(=O)Nc1ccc(CC2=CN3C(C)=C(C)NC3C(c3cccc(Cl)c3)=C2)cn1

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7913078 0.88 DYRK3 (0.37)
SCHEMBL7920535 0.81 DHFR (0.33)
SCHEMBL7914652 0.79 DYRK3 (0.37) MEN1KMT2A
SCHEMBL7916616 0.79 PDE4D (0.48) MEN1KMT2A
SCHEMBL7929296 0.78 DYRK3 (0.49)
SCHEMBL7913175 0.76 MAOB (0.33)
SCHEMBL7917981 0.76 DYRK3 (0.35) MEN1KMT2A
SCHEMBL7902850 0.74 PGR (0.33) MEN1KMT2A
SCHEMBL7911681 0.72 MAPT (0.36) MEN1KMT2A
SCHEMBL7930844 0.72 PGR (0.33) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010059838-A2 PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS DECODE GENETICS EHF (IS) 2010-05-27 WO disclosed
WO-2010059836-A1 SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE DECODE GENETICS EHF (IS) 2010-05-27 WO disclosed