Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.31 |
| ▸ | STK4 | Q13043 | 1/20 | 0.31 |
| ▸ | STK3 | Q13188 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7913175 | 0.88 | MAOB (0.33) | IKBKESTK4STK3LRRK2TAAR1 | |
| SCHEMBL7915334 | 0.84 | DHFR (0.32) | DHFRPTPN11IKBKESTK4STK3 | |
| SCHEMBL7911726 | 0.82 | — | — | |
| SCHEMBL7915330 | 0.81 | MEN1 (0.36) | — | |
| SCHEMBL7902850 | 0.79 | PGR (0.33) | — | |
| SCHEMBL7902988 | 0.73 | GRIN1 (0.32) | — | |
| SCHEMBL7917010 | 0.72 | MAOB (0.33) | IKBKESTK4STK3LRRK2TAAR1 | |
| SCHEMBL7911301 | 0.72 | NLRP3 (0.35) | — | |
| SCHEMBL7911681 | 0.72 | MAPT (0.36) | — | |
| SCHEMBL7902852 | 0.71 | NPC1 (0.34) | STK4STK3LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |