Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.31 |
| ▸ | STK4 | Q13043 | 1/20 | 0.31 |
| ▸ | STK3 | Q13188 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.30 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.30 |
| ▸ | CCND1 | P24385 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7920535 | 0.88 | DHFR (0.33) | TAAR1IKBKESTK4STK3LRRK2 | |
| SCHEMBL7917010 | 0.84 | MAOB (0.33) | MAOBTAAR1IKBKESTK4STK3 | |
| SCHEMBL7902850 | 0.83 | PGR (0.33) | ALDH1A1LMNAMAPTALOX12SMN1; SMN2 | |
| SCHEMBL7915330 | 0.76 | MEN1 (0.36) | — | |
| SCHEMBL7911301 | 0.75 | NLRP3 (0.35) | ALDH1A1LMNASMN1; SMN2PGR | |
| SCHEMBL7915334 | 0.71 | DHFR (0.32) | TAAR1IKBKESTK4STK3LRRK2 | |
| SCHEMBL7902988 | 0.67 | GRIN1 (0.32) | LMNASMN1; SMN2 | |
| SCHEMBL7916993 | 0.65 | ESR2 (0.35) | ALDH1A1LMNAMAPTALOX12PGR | |
| SCHEMBL7902852 | 0.65 | NPC1 (0.34) | STK4STK3LRRK2MAPTSMN1; SMN2 | |
| SCHEMBL7902845 | 0.64 | PIM1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |