Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 4/20 | 0.35 |
| ▸ | PLG | P00747 | 3/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | PLAT | P00750 | 2/20 | 0.35 |
| ▸ | KLK1 | P06870 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | MELK | Q14680 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16502832 | 0.85 | SLC9A1 (0.49) | TNFHIPK2HTR2CSLC9A1HTR5A | |
| SCHEMBL7919781 | 0.81 | TNF (0.54) | TNFKDM4EHIPK2HTR2CHDAC6 | |
| SCHEMBL7919941 | 0.81 | PLAU (0.41) | KDM4EPLAUPLGF2PLAT | |
| SCHEMBL7923307 | 0.80 | CHEK1 (0.35) | PLAUPLGF2PLATKLK1 | |
| SCHEMBL7918227 | 0.77 | SLC9A1 (0.48) | HTR2CSLC9A1HTR5A | |
| SCHEMBL7915669 | 0.76 | HTR5A (0.41) | PLAUPLGF2PLATKLK1 | |
| SCHEMBL16502698 | 0.76 | TNF (0.54) | TNFHIPK2PLAU | |
| SCHEMBL7919998 | 0.74 | HTR5A (0.51) | HTR2CSLC9A1HTR5A | |
| SCHEMBL7918261 | 0.74 | HTR5A (0.48) | HTR2CSLC9A1HTR5A | |
| SCHEMBL16502744 | 0.74 | HTR5A (0.51) | SLC9A1HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090304-A1 | ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-12 | — | — | WO | disclosed |