Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 7/20 | 0.41 |
| ▸ | PLG | P00747 | 6/20 | 0.41 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | HTR5A | P47898 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 3/20 | 0.35 |
| ▸ | KLK1 | P06870 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | F12 | P00748 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16502809 | 0.86 | HTR5A (0.53) | PLAUF2HTR5AHTR2AHTR7 | |
| SCHEMBL7915669 | 0.84 | HTR5A (0.41) | PLAUPLGF2HTR5APLAT | |
| SCHEMBL7917427 | 0.82 | F2 (0.41) | PLAUPLGF2BCHENPC1 | |
| SCHEMBL12874632 | 0.81 | PLAU (0.46) | PLAUPLGF2HTR5APLAT | |
| SCHEMBL7916046 | 0.81 | HTR5A (0.39) | PLAUPLGF2HTR5APLAT | |
| SCHEMBL7916601 | 0.81 | TNF (0.43) | PLAUPLGF2HTR5APLAT | |
| SCHEMBL16502684 | 0.77 | PLAU (0.50) | PLAUF2BCHENPC1MAPT | |
| SCHEMBL7918769 | 0.77 | CNR2 (0.39) | PLAUPLGF2PLATKLK1 | |
| SCHEMBL16502716 | 0.73 | ALDH1A1 (0.48) | PLAUF2NPC1MAPTRAB9A | |
| SCHEMBL7923307 | 0.73 | CHEK1 (0.35) | PLAUPLGF2HTR5APLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090304-A1 | ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-12 | — | — | WO | disclosed |