Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PKLR | P30613 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5065262 | 0.88 | ALDH1A1 (0.46) | ALDH1A1HSD17B10TDP1ALOX15LMNA | |
| SCHEMBL27523713 | 0.88 | ACHE (0.43) | ALDH1A1HSD17B10TDP1ALOX15LMNA | |
| SCHEMBL27488196 | 0.86 | ALDH1A1 (0.46) | ALDH1A1HSD17B10TDP1ALOX15LMNA | |
| SCHEMBL27684435 | 0.84 | LMNA (0.44) | ALDH1A1ALOX15LMNACES2CES1 | |
| SCHEMBL5052286 | 0.84 | TSHR (0.43) | ALDH1A1HSD17B10TDP1ALOX15LMNA | |
| SCHEMBL27534125 | 0.82 | CES2 (0.46) | ALDH1A1HSD17B10TDP1ALOX15LMNA | |
| SCHEMBL995202 | 0.82 | ACHE (0.71) | ALDH1A1HSD17B10TDP1ALOX15LMNA | |
| SCHEMBL1711718 | 0.82 | CA1 (0.43) | ALDH1A1HSD17B10TDP1ALOX15LMNA | |
| SCHEMBL29352330 | 0.79 | — | — | |
| SCHEMBL45406 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106831814-A | A kind of thieno [3,2 d] RTIs of miazines HIV 1 and its preparation method and application | 山东大学 | 2017-06-13 | — | — | CN | disclosed |
| CN-106749317-A | A kind of azepine penthienate [2,3 d] pyrimidone benzsulfamide analog derivative and purposes | 中国科学院新疆理化技术研究所 | 2017-05-31 | — | — | CN | disclosed |
| US-9453023-B2 | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof | SANOFI (FR) | 2016-09-27 | — | — | US | disclosed |
| CN-105461712-A | Pyrido[1,2-a]pyrimidone analogs as mTOR/PI3K inhibitors | NANJING MINGDE DRUG R & D CO LTD | 2016-04-06 | — | — | CN | disclosed |
| CN-105461711-A | Pyrido[1,2-a]pyrimidone analogs as PI3K inhibitors | NANJING MINGDE DRUG R & D CO LTD | 2016-04-06 | — | — | CN | disclosed |
| CN-103936762-B | Morpholine quinolines, Preparation Method And The Use | SHANGHAI HUILUN LIFE SCIENCE & TECHNOLOGY Co.,Ltd. (CN) | 2016-02-24 | — | — | CN | disclosed |
| CN-104418867-A | Compound used as PI3K/mTOR inhibitor, preparation method and application | SHANGHAI HUILUN LIFE SCIENCE & TECHNOLOGY CO LTD | 2015-03-18 | — | — | CN | disclosed |
| EP-2569280-B1 | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof | SANOFI SA (FR) | 2015-02-25 | — | — | EP | disclosed |
| CN-102746241-B | 2, 3, 5-trisubstituted benzamide compound, and preparation method and application thereof | UNIV XI AN JIAOTONG | 2014-11-05 | — | — | CN | disclosed |
| US-20140275005-A1 | SUBSTITUTED PHENYL CYCLOALKYL PYRROLIDINE (PIPERIDINE) SPIROLACTAMS AND AMIDES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2014-09-18 | — | — | US | disclosed |
| CN-1451007-A | Adenosine A2aReceptor antagonists | SCHERING CORP (US) | 2003-10-22 | — | — | CN | disclosed |
| WO-2003070244-A1 | ANTAGONIST OF MELANIN CONCENTRATING HORMONE AND THEIR USES | ABBOTT LABORATORIES (US) | 2003-08-28 | — | — | WO | disclosed |
| CN-1112356-C | Nitromethylthiobenzene derivatives as inhibitors of aldose reductase | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | CN | disclosed |
| CN-1303281-A | Application of compound in enhancing activity of pyruvate dehydrogenase | ASTRA ZENECA LTD (SE) | 2001-07-11 | — | — | CN | disclosed |
| CN-1061339-C | Novel sulfonamide inhibitors of aspartyl protease | VERTEX PHARMA (US) | 2001-01-31 | — | — | CN | disclosed |
| CN-1247537-A | Sulfonamide compounds having 5-HT receptor activity | KNOLL AG (DE) | 2000-03-15 | — | — | CN | disclosed |
| CN-1241997-A | Nitromethylthiobenzene derivatives as inhibitors of aldose reductase | MERCK PATENT GMBH (DE) | 2000-01-19 | — | — | CN | disclosed |
| CN-1087347-A | The new sulfonamide inhibitors of aspartyl protease | VERTEX PHARMA (US) | 1994-06-01 | — | — | CN | disclosed |
| US-5212301-A | SUBSTITUTED FLUOROBENZENES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-05-18 | — | — | US | disclosed |
| EP-0512715-A2 | Verfahren zur Herstellung einer in 3-Stellung fluorierten aromatischen Verbindung | ZENECA LIMITED (GB) | 1992-11-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275005-A1 | SUBSTITUTED PHENYL CYCLOALKYL PYRROLIDINE (PIPERIDINE) SPIROLACTAMS AND AMIDES, PREPARATION AND THERAPEUTIC USE THEREOF | PRLHR, TACR1, TACR2 | ALDH1A1 491/4885HSD17B10 2277/4885TDP1 3665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.