Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.52 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1117015 | 0.92 | MAPT (0.66) | MAPTHPGDL3MBTL1MTNR1AMTNR1B | |
| SCHEMBL8029095 | 0.85 | PDE4B (0.64) | MAPTHPGDL3MBTL1MTNR1AMTNR1B | |
| SCHEMBL6850906 | 0.85 | L3MBTL1 (0.65) | HPGDL3MBTL1PARP10ALDH1A1 | |
| SCHEMBL29800739 | 0.84 | CHRM2 (0.57) | MAPTHPGDMTNR1AMTNR1BGAA | |
| Hydrochloric Acid SCHEMBL8981950 | 0.83 | PDE4B (0.62) | MAPTHPGDL3MBTL1MTNR1AMTNR1B | |
| SCHEMBL8981940 | 0.83 | MAPT (0.59) | MAPTHPGDL3MBTL1MTNR1AMTNR1B | |
| SCHEMBL7923893 | 0.82 | LTA4H (0.53) | L3MBTL1PARP10 | |
| SCHEMBL7928218 | 0.81 | L3MBTL1 (0.76) | MAPTHPGDL3MBTL1GAALMNA | |
| SCHEMBL10533621 | 0.81 | LMNA (0.58) | MAPTHPGDL3MBTL1MTNR1AMTNR1B | |
| SCHEMBL6851369 | 0.81 | KMT2A (0.58) | HPGDSMN1; SMN2LMNAALPLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039256-A1 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2010-04-08 | — | — | WO | disclosed |