SCHEMBL7918690

SCHEMBL7918690

O=C(CN(Cc1ccccc1)S(=O)(=O)Cc1ccccc1)NO

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.60
CA2 P00918 2/20 0.60
MMP1 P03956 1/20 0.60
MMP2 P08253 1/20 0.60
MMP9 P14780 1/20 0.60
MMP8 P22894 1/20 0.60
MMP13 P45452 1/20 0.60
MEP1B Q16820 5/20 0.52
MEP1A Q16819 1/20 0.52
CNR2 P34972 2/20 0.51
RORC P51449 7/20 0.51
GAA P10253 1/20 0.48
MMP3 P08254 1/20 0.48
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
RORA P35398 2/20 0.47
NR1H2 P55055 2/20 0.47
NR1H3 Q13133 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5281753 0.85 CNR2 (0.55) CA2CNR2RORCRORANR1H2
SCHEMBL8039632 0.84 MMP3 (0.57) CA1CA2MMP1MMP2MMP9
SCHEMBL8041132 0.83 BMP1 (0.58) CA1CA2MMP1MMP2MMP9
SCHEMBL2845552 0.83 MEP1B (0.68) CA1CA2MMP1MMP2MMP9
SCHEMBL10478607 0.83 RORC (0.61) CA2CNR2RORCRORANR1H2
SCHEMBL7686664 0.82 MMP2 (0.57) CA1CA2MMP1MMP2MMP9
SCHEMBL6411529 0.81 BMP1 (0.53) CA1CA2MMP1MMP2MMP9
SCHEMBL31165765 0.81 CNR2 (0.51) CNR2RORCKMT2ARORANR1H2
SCHEMBL8037741 0.80 CNR2 (0.59) CA1CA2MMP1MMP2MMP9
SCHEMBL8041116 0.80 MMP2 (0.55) CA1CA2MMP1MMP2MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6228988-B1 SOLID PHASE SYNTHESIS BY FORMING MIXTURE OF LIQUID AND SOLID PHASE REACTION PRODUCT, CLEAVING PRODUCT FROM SOLID PHASE, DEPROTECTING THE NITROGEN IF NECESSARY, SEPARATING LIQUID AND SOLID REACTION PHASE, AND RECOVERING PRODUCT BRITISH BIOTECH PHARMACEUTICALS, LTD. (GB) 2001-05-08 US disclosed
US-6093798-A SOLID PHASE REACTION PRODUCT OF HYDROXYLAMINE OR PROTECTED HYDROXYLAMINE GROUPS LINKED TO INSOLUBLE SUPPORT THROUGH ACID OR PHOTOLYSIS CLEAVABLE LINKER; FOR PRODUCTION OF ENZYME INHIBITORS OF ZINC METALLOPROTEINASE ENZYMES BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 2000-07-25 US disclosed
US-5932695-A SOLID PHASE BIOSYNTHESIS; COMBINATORIAL LIBRARIES BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) 1999-08-03 US disclosed
EP-0811019-B1 SYNTHESIS OF HYDROXAMIC ACID DERIVATIVES BRITISH BIOTECH PHARM (GB) 1999-04-07 EP disclosed
EP-0811019-A1 SYNTHESIS OF HYDROXAMIC ACID DERIVATIVES BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1997-12-10 EP disclosed
WO-1996026223-A1 SYNTHESIS OF HYDROXAMIC ACID DERIVATIVES BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1996-08-29 WO disclosed