Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7920089 | 0.85 | HSP90AA1 (0.49) | KDM4EALDH1A1DCTPP1MAPTTP53 | |
| SCHEMBL7920187 | 0.82 | DCTPP1 (0.48) | KDM4EALDH1A1DCTPP1MAPTTP53 | |
| SCHEMBL32688343 | 0.82 | DCTPP1 (0.48) | KDM4EALDH1A1DCTPP1MAPTTP53 | |
| SCHEMBL8092506 | 0.81 | ALDH1A1 (0.55) | KDM4EALDH1A1MAPTTP53PDE5A | |
| SCHEMBL7920472 | 0.80 | DCTPP1 (0.48) | KDM4EALDH1A1DCTPP1MAPTTP53 | |
| SCHEMBL1661610 | 0.78 | KDM4E (0.62) | KDM4EALDH1A1MAPTTP53GAA | |
| SCHEMBL16379086 | 0.77 | METTL3 (0.44) | KDM4EALDH1A1ADORA3ADORA1 | |
| SCHEMBL8101681 | 0.76 | KDM4E (0.61) | KDM4EALDH1A1MAPTTP53GAA | |
| SCHEMBL8105784 | 0.76 | KDM4E (0.52) | KDM4EALDH1A1MAPTTP53PKM | |
| SCHEMBL7920397 | 0.75 | HSP90AA1 (0.50) | KDM4EALDH1A1DCTPP1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6229016-B1 | PYRIDOPYRIMIDINE DERIVATIVES AS CHEMICAL INTERMEDIATES; POLYMERIZATION INHIBITION OF TUBULIN | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2001-05-08 | — | — | US | disclosed |
| US-6071930-A | FOR INHIBITION OF MITOSIS OR TUMOR GROWTH | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-06-06 | — | — | US | disclosed |
| US-5994367-A | PREVENT CELL MITOSIS; ANTICARCINOGENIC AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-11-30 | — | — | US | disclosed |