Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6526039 | 0.74 | ALDH1A1 (0.35) | ALDH1A1MAPK1KDM4ELMNACYP2A6 | |
| Hydrochloric Acid SCHEMBL7929752 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL4062027 | 0.73 | ALDH1A1 (0.34) | ALDH1A1MAPK1KDM4ELMNACYP2A6 | |
| Hydrochloric Acid SCHEMBL7197636 | 0.65 | HTR1A (0.33) | ALDH1A1KDM4ELMNAMAPTHPGD | |
| Hydrochloric Acid SCHEMBL622158 | 0.64 | DHFR (0.33) | ALDH1A1MAPK1KDM4ECYP2A6MAPT | |
| Hydrochloric Acid SCHEMBL2119949 | 0.64 | ALDH1A1 (0.35) | ALDH1A1MAPK1KDM4ELMNACYP2A6 | |
| Hydrochloric Acid SCHEMBL1129509 | 0.64 | ALDH1A1 (0.35) | ALDH1A1MAPK1KDM4ELMNACYP2A6 | |
| Hydrochloric Acid SCHEMBL219041 | 0.63 | HTR7 (0.34) | ALDH1A1CYP2A6MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL6905620 | 0.62 | CES1 (0.34) | ALDH1A1HPGDHSD17B10CYP1A2 | |
| Hydrochloric Acid SCHEMBL4326066 | 0.62 | KDM4E (0.32) | ALDH1A1MAPK1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153938-A1 | CATALYST FOR STEREOREGULAR POLYMERIZATION OF ALPHA-OLEFIN AND PROCESS FOR PRODUCING STEREOREGULAR ALPHA-OLEFIN POLYMER | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2001-11-14 | — | — | EP | disclosed |