SCHEMBL7921180

SCHEMBL7921180

N#Cc1ccc(Nc2c(F)c3c(c(F)c2Oc2ccccc2)C(=O)c2c(O)ccc(O)c2C3=O)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CXCR2 P25025 2/20 0.44
MAP2K1 Q02750 3/20 0.38
RAF1 P04049 1/20 0.37
KDM4E B2RXH2 1/20 0.37
MEN1 O00255 1/20 0.37
LMNA P02545 1/20 0.37
POLB P06746 1/20 0.37
MAPT P10636 1/20 0.37
PKM P14618 1/20 0.37
MAPK1 P28482 1/20 0.37
RAB9A P51151 1/20 0.37
KMT2A Q03164 1/20 0.37
IL18 Q14116 1/20 0.37
CYP11B1 P15538 2/20 0.37
CSNK1A1 P48729 1/20 0.36
CSNK1D P48730 1/20 0.36
PGR P06401 1/20 0.35
STK10 O94804 1/20 0.35
SLK Q9H2G2 1/20 0.35
TOP2A P11388 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6652507 0.90 STK10 (0.39) CXCR2MAP2K1RAF1KDM4EMEN1
SCHEMBL7930030 0.89 CA12 (0.40) CXCR2MEN1LMNAPOLBMAPT
SCHEMBL8733582 0.85 TAS1R3 (0.39) CXCR2KDM4EMEN1LMNAPOLB
SCHEMBL7933227 0.83 CXCR2 (0.46) CXCR2LMNAMAPTTOP2ATOP2B
SCHEMBL7930796 0.81 CXCR2 (0.44) CXCR2LMNAMAPTTOP2ATOP2B
SCHEMBL7930614 0.79 ADAMTS5 (0.40) CXCR2KDM4ECA12CA1CA2
SCHEMBL7927152 0.77 MEN1 (0.40) MEN1POLBMAPTKMT2APGR
SCHEMBL7933074 0.77 TBXA2R (0.38) CXCR2KDM4ERAB9A
SCHEMBL6652697 0.76 MAPT (0.44) CXCR2MEN1MAPTKMT2ATOP2A
SCHEMBL6652489 0.74 MAPT (0.34) CXCR2KDM4ELMNAMAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0661350-B1 Quinizarin compound, method for production thereof, and use therefor NIPPON CATALYTIC CHEM IND (JP) 2001-08-22 EP disclosed
US-5817843-A Quinizarin compound, method for production thereof, and use therefor NIPPON SHOKUBAI CO., LTD. (JP) 1998-10-06 US disclosed
US-5608091-A SHEETS FOR HEAT EXCHANGING AND OPTICAL RECORDING MATERIAL NIPPON SHOKUBAI CO., LTD. (JP) 1997-03-04 US disclosed
EP-0661350-A1 Quinizarin compound, method for production thereof, and use therefor NIPPON SHOKUBAI CO., LTD. (JP) 1995-07-05 EP disclosed