Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.45 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.45 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7922651 | 0.85 | ALDH1A1 (0.59) | MAPTALDH1A1KDM4EMAPK1BLM | |
| SCHEMBL7920537 | 0.75 | MAPT (0.46) | MAPTALDH1A1KDM4EMAPK1BLM | |
| SCHEMBL7829737 | 0.72 | ALDH1A1 (0.73) | MAPTALDH1A1LMNATP53HTT | |
| SCHEMBL7922254 | 0.72 | ALDH1A1 (0.44) | MAPTALDH1A1KDM4EMAPK1BLM | |
| SCHEMBL7922643 | 0.70 | TASP1 (0.62) | MAPTALDH1A1KDM4EMAPK1LMNA | |
| SCHEMBL7922259 | 0.67 | TASP1 (0.61) | MAPTALDH1A1KDM4EMAPK1LMNA | |
| SCHEMBL20535404 | 0.66 | HDAC6 (1.00) | ALDH1A1LMNATP53HDAC6 | |
| SCHEMBL38657407 | 0.65 | KMO (0.47) | MAPTALDH1A1KDM4EMAPK1BLM | |
| SCHEMBL20552675 | 0.65 | TP53 (0.52) | MAPTALDH1A1KDM4ELMNATP53 | |
| SCHEMBL21749252 | 0.64 | TP53 (0.51) | MAPTALDH1A1KDM4ELMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100500-A1 | THE USE OF CD4-BINDING SMALL MOLECULES TO INHIBIT HIV INFECTION | THOMAS JEFFERSON UNIVERSITY (US) | 2001-05-23 | — | — | EP | claimed |
| WO-2000004903-A1 | THE USE OF CD4-BINDING SMALL MOLECULES TO INHIBIT HIV INFECTION | THOMAS JEFFERSON UNIVERSITY (US) | 2000-02-03 | — | — | WO | claimed |
| EP-1100500-A1 | THE USE OF CD4-BINDING SMALL MOLECULES TO INHIBIT HIV INFECTION | THOMAS JEFFERSON UNIVERSITY (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000004903-A1 | THE USE OF CD4-BINDING SMALL MOLECULES TO INHIBIT HIV INFECTION | THOMAS JEFFERSON UNIVERSITY (US) | 2000-02-03 | — | — | WO | disclosed |