SCHEMBL7922254

SCHEMBL7922254

NC=S.O=C(Cn1nnc(-c2cc(Cl)cc(Cl)c2)n1)NNc1ccccc1F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.44
KDM4E B2RXH2 4/20 0.44
MAPT P10636 2/20 0.44
MAPK1 P28482 2/20 0.44
BLM P54132 1/20 0.44
POLB P06746 4/20 0.44
KMT2A Q03164 7/20 0.42
MEN1 O00255 6/20 0.42
LMNA P02545 1/20 0.41
ATM Q13315 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
GAA P10253 1/20 0.41
HTT P42858 1/20 0.41
KCNJ6 P48051 2/20 0.41
KCNJ5 P48544 2/20 0.41
KCNJ3 P48549 2/20 0.41
HSD17B10 Q99714 1/20 0.41
RXFP1 Q9HBX9 1/20 0.40
TP53 P04637 1/20 0.39
HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7920537 0.78 MAPT (0.46) ALDH1A1KDM4EMAPTMAPK1BLM
SCHEMBL7922641 0.72 MAPT (0.61) ALDH1A1KDM4EMAPTMAPK1BLM
SCHEMBL7922651 0.69 ALDH1A1 (0.59) ALDH1A1KDM4EMAPTMAPK1BLM
SCHEMBL14096406 0.69 ALDH1A1 (0.54) ALDH1A1KDM4EMAPTMAPK1BLM
SCHEMBL7922643 0.68 TASP1 (0.62) ALDH1A1KDM4EMAPTMAPK1POLB
SCHEMBL19538024 0.68 POLB (0.55) ALDH1A1KDM4EMAPTPOLBKMT2A
SCHEMBL14096409 0.66 ALDH1A1 (0.52) ALDH1A1KDM4EMAPTMAPK1BLM
SCHEMBL7922259 0.65 TASP1 (0.61) ALDH1A1KDM4EMAPTMAPK1POLB
SCHEMBL38655969 0.63 KMO (0.48) ALDH1A1MAPTPOLBKMT2AMEN1
SCHEMBL8215669 0.63 HPGD (0.70) ALDH1A1KDM4EMAPTPOLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1100500-A1 THE USE OF CD4-BINDING SMALL MOLECULES TO INHIBIT HIV INFECTION THOMAS JEFFERSON UNIVERSITY (US) 2001-05-23 EP claimed
WO-2000004903-A1 THE USE OF CD4-BINDING SMALL MOLECULES TO INHIBIT HIV INFECTION THOMAS JEFFERSON UNIVERSITY (US) 2000-02-03 WO claimed
EP-1100500-A1 THE USE OF CD4-BINDING SMALL MOLECULES TO INHIBIT HIV INFECTION THOMAS JEFFERSON UNIVERSITY (US) 2001-05-23 EP disclosed
WO-2000004903-A1 THE USE OF CD4-BINDING SMALL MOLECULES TO INHIBIT HIV INFECTION THOMAS JEFFERSON UNIVERSITY (US) 2000-02-03 WO disclosed